The book begins by laying the groundwork with the history and fundamentals of antibiotic resistance. The book progresses through sections examining overuse in different sectors, the role of environmental factors such as wastewater, and the potential of new treatments. It concludes with actionable policy recommendations for effective stewardship at all levels, supported by data from epidemiological studies and genomic analyses. Ultimately, it provides a balanced view to inform better practices in prescribing, infection control, and policy-making to combat infectious diseases.