Cell Culture Engineering

┬╖ Advances in Biochemical Engineering/Biotechnology рдкреБрд╕реНрддрдХ 101 ┬╖ Springer
рдИ-рдмреБрдХ
168
рдкреЗрдЬ
рд░реЗрдЯрд┐рдВрдЧ рдФрд░ рд╕рдореАрдХреНрд╖рд╛рдУрдВ рдХреА рдкреБрд╖реНрдЯрд┐ рдирд╣реАрдВ рд╣реБрдИ рд╣реИ ┬ардЬрд╝реНрдпрд╛рджрд╛ рдЬрд╛рдиреЗрдВ

рдЗрд╕ рдИ-рдмреБрдХ рдХреЗ рдмрд╛рд░реЗ рдореЗрдВ рдЬрд╛рдирдХрд╛рд░реА

Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.

рдЗрд╕ рдИ-рдмреБрдХ рдХреЛ рд░реЗрдЯрд┐рдВрдЧ рджреЗрдВ

рд╣рдореЗрдВ рдЕрдкрдиреА рд░рд╛рдп рдмрддрд╛рдПрдВ.

рдкрдарди рдЬрд╛рдирдХрд╛рд░реА

рд╕реНрдорд╛рд░реНрдЯрдлрд╝реЛрди рдФрд░ рдЯреИрдмрд▓реЗрдЯ
Android рдФрд░ iPad/iPhone рдХреЗ рд▓рд┐рдП Google Play рдХрд┐рддрд╛рдмреЗрдВ рдРрдкреНрд▓рд┐рдХреЗрд╢рди рдЗрдВрд╕реНрдЯреЙрд▓ рдХрд░реЗрдВ. рдпрд╣ рдЖрдкрдХреЗ рдЦрд╛рддреЗ рдХреЗ рд╕рд╛рде рдЕрдкрдиреЗ рдЖрдк рд╕рд┐рдВрдХ рд╣реЛ рдЬрд╛рддрд╛ рд╣реИ рдФрд░ рдЖрдкрдХреЛ рдХрд╣реАрдВ рднреА рдСрдирд▓рд╛рдЗрди рдпрд╛ рдСрдлрд╝рд▓рд╛рдЗрди рдкрдврд╝рдиреЗ рдХреА рд╕реБрд╡рд┐рдзрд╛ рджреЗрддрд╛ рд╣реИ.
рд▓реИрдкрдЯреЙрдк рдФрд░ рдХрдВрдкреНрдпреВрдЯрд░
рдЖрдк рдЕрдкрдиреЗ рдХрдВрдкреНрдпреВрдЯрд░ рдХреЗ рд╡реЗрдм рдмреНрд░рд╛рдЙрдЬрд╝рд░ рдХрд╛ рдЙрдкрдпреЛрдЧ рдХрд░рдХреЗ Google Play рдкрд░ рдЦрд░реАрджреА рдЧрдИ рдСрдбрд┐рдпреЛ рдХрд┐рддрд╛рдмреЗрдВ рд╕реБрди рд╕рдХрддреЗ рд╣реИрдВ.
eReaders рдФрд░ рдЕрдиреНрдп рдбрд┐рд╡рд╛рдЗрд╕
Kobo рдИ-рд░реАрдбрд░ рдЬреИрд╕реА рдИ-рдЗрдВрдХ рдбрд┐рд╡рд╛рдЗрд╕реЛрдВ рдкрд░ рдХреБрдЫ рдкрдврд╝рдиреЗ рдХреЗ рд▓рд┐рдП, рдЖрдкрдХреЛ рдлрд╝рд╛рдЗрд▓ рдбрд╛рдЙрдирд▓реЛрдб рдХрд░рдХреЗ рдЙрд╕реЗ рдЕрдкрдиреЗ рдбрд┐рд╡рд╛рдЗрд╕ рдкрд░ рдЯреНрд░рд╛рдВрд╕рдлрд╝рд░ рдХрд░рдирд╛ рд╣реЛрдЧрд╛. рдИ-рд░реАрдбрд░ рдкрд░ рдХрд╛рдо рдХрд░рдиреЗ рд╡рд╛рд▓реА рдлрд╝рд╛рдЗрд▓реЛрдВ рдХреЛ рдИ-рд░реАрдбрд░ рдкрд░ рдЯреНрд░рд╛рдВрд╕рдлрд╝рд░ рдХрд░рдиреЗ рдХреЗ рд▓рд┐рдП, рд╕рд╣рд╛рдпрддрд╛ рдХреЗрдВрджреНрд░ рдХреЗ рдирд┐рд░реНрджреЗрд╢реЛрдВ рдХрд╛ рдкрд╛рд▓рди рдХрд░реЗрдВ.