Hypoxia and Cancer Metastasis

· Springer
Ebook
160
Pages
Ratings and reviews aren’t verified  Learn More

About this ebook

The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments.

This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.

About the author

Assistant Professor of Oncology
Assistant Professor Chemical and Molecular Engineering
Johns Hopkins University School of Medicine
Baltimore, Maryland
Jayne Koskinas Ted Giovanis Foundation for Health and Policy Partnership

Daniele Gilkes earned her MS in engineering from the University of Florida and her PhD in cancer biology from the University of South Florida. She is currently an assistant professor in the departments of Oncology as well as Chemical and Molecular Engineering at the Johns Hopkins University School of Medicine. Her research goal is to develop a breast cancer research program which utilizes new technologies that can rapidly advance our understanding of how the microenvironment, in particular hypoxia and hypoxia-induced genetic changes, promote breast cancer metastasis. The overall objective is to identify therapeutic strategies that focus on metastasis treatment and prevention strategies for breast cancer patients.

Current Research
Seeking to understand the timing and requirements for metastasis.
Using both mathematics and cancer biology to chart the process of metastasis.
These innovate cross-disciplinary studies will accelerate our understanding of metastasis and guide new therapy development to prevent metastasis in breast cancer survivors.

Rate this ebook

Tell us what you think.

Reading information

Smartphones and tablets
Install the Google Play Books app for Android and iPad/iPhone. It syncs automatically with your account and allows you to read online or offline wherever you are.
Laptops and computers
You can listen to audiobooks purchased on Google Play using your computer's web browser.
eReaders and other devices
To read on e-ink devices like Kobo eReaders, you'll need to download a file and transfer it to your device. Follow the detailed Help Center instructions to transfer the files to supported eReaders.