Dive into the depths of esophageal diverticulum with our comprehensive treatise, offering a detailed exploration from pathophysiology to precision management. Discover the latest insights into this complex condition, including its classification, epidemiology, etiology, and risk factors. Uncover the structural intricacies of the esophagus, delve into its innervation and blood supply, and unravel the mysteries of peristalsis and motility. Explore each subtype of esophageal diverticulum, from Zenker's and epiphrenic to traction and pulsion, understanding their clinical features and underlying mechanisms. Navigate through advanced diagnostic technologies and emerging therapeutic targets, gaining invaluable knowledge for clinical practice. With evidence-based insights and innovative approaches, this treatise equips clinicians and researchers with the tools needed to tackle esophageal diverticulum comprehensively and effectively.