Explore the comprehensive treatise on duodenal cancer, delving deep into its intricacies from epidemiology and etiology to cutting-edge molecular diagnostics and novel therapeutic avenues. This exhaustive guide navigates through the anatomical, biochemical, and clinical landscapes of duodenal cancer, offering a holistic understanding. Discover the latest advancements in targeted therapies, immunotherapies, and integrative approaches, providing patients and healthcare professionals with valuable insights into personalized treatment strategies. With a focus on multidisciplinary collaboration and evidence-based practice, this treatise serves as a vital resource for oncologists, surgeons, nurses, and researchers seeking to optimize patient care and outcomes in the complex realm of duodenal cancer.