Explore an extensive treatise on Episcleritis, a complex inflammatory ocular condition, delving into its definition, epidemiology, etiology, classification, and clinical manifestations. Dive into the intricacies of its pathophysiology, immunological characteristics, and diagnostic evaluation, including ocular imaging and laboratory investigations. Discover comprehensive insights into treatment modalities, from pharmacological interventions to surgical techniques, integrating emerging technologies and personalized approaches. Uncover unexplored areas of research, such as genetic susceptibility, environmental triggers, and ocular surface biomarkers, offering opportunities for innovation and advancement. With a focus on holistic health and patient-centered care, this treatise provides a thorough examination of Episcleritis, empowering clinicians, researchers, and patients with invaluable knowledge to optimize management strategies and improve outcomes.