Explore the comprehensive treatise on Giant Cell Tumors of Bone, delving into the intricate facets of this challenging condition. From its definition and classification to advanced molecular mechanisms, bone structure, and histopathological examinations, each chapter offers in-depth insights. Discover how epidemiology, etiology, and risk factors intertwine with diagnostic imaging modalities, differential diagnosis, and treatment approaches, including novel targeted therapies and immunotherapy. Uncover the significance of exercise, psychological support, and nutritional considerations in optimizing patient outcomes. With evidence-based interventions and multidisciplinary collaboration at its core, this treatise provides a holistic approach to managing Giant Cell Tumors of Bone, aiming to enhance survivorship, quality of life, and overall well-being for patients and caregivers alike.