Dive into the intricate world of Glioblastoma Multiforme with our comprehensive treatise, exploring its pathophysiology, treatment modalities, and prognostic insights. From understanding the genetic alterations driving this aggressive brain cancer to delving into the latest advancements in surgery, radiation therapy, and immunotherapy, this guide equips readers with in-depth knowledge essential for medical professionals and researchers. Discover how lifestyle modifications, psychosocial support, and integrative medicine can complement conventional treatments, empowering patients on their journey to confront and manage Glioblastoma. Whether you're seeking to expand your medical expertise or support a loved one facing this diagnosis, this treatise offers a holistic perspective, grounded in scientific evidence and aimed at fostering hope and empowerment in the face of adversity.