Explore the intricate world of pediatric headaches in this comprehensive treatise, offering deep insights into evaluation, management strategies, and long-term care. Delve into the neuroanatomy, vascular dynamics, and musculoskeletal aspects relevant to childhood headaches. Discover detailed discussions on primary and secondary headache types, including migraine, tension-type, and their atypical presentations. Uncover the role of genetics, environmental triggers, and neurochemical pathways influencing pediatric headaches. Gain valuable knowledge on diagnostic criteria, imaging techniques, and laboratory tests essential for accurate diagnosis. Explore holistic approaches including non-pharmacological interventions, pharmacological treatments, and their application in special pediatric populations. This treatise is essential for healthcare professionals seeking to enhance their understanding, optimize treatment outcomes, and improve the quality of life for children and adolescents affected by headaches.