Genetic and Epigenetic Foundations, Molecular Basis, and Mechanistic Pathways of Chronic Inflammation-Driven Tumorigenesis: Targeting NF-κB and STAT3 Signaling
jaan 2025 · Black Mill Publishing
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Chronic inflammation is a silent yet powerful driver of cancer, altering genetic and epigenetic landscapes to promote tumor progression, immune evasion, and therapy resistance. This comprehensive volume unpacks the intricate molecular mechanisms linking inflammation and oncogenesis, from oxidative DNA damage to epigenetic modifications that rewire cellular fate.
Examining key pathways such as NF-κB, STAT3, and TGF-β, this text provides a rigorous yet accessible analysis of inflammation-driven tumorigenesis. With a focus on genetic mutations, histone modifications, and therapeutic targets, it bridges fundamental research with clinical implications, offering insights into novel intervention strategies.
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Jeff Radwell was born into a lineage of educators, reformers, and leaders in humanitarian service. In addition to befriending every dog he meets, he enjoys literature, ceramics, gardening, and architectural design. His work, whether in science, writing, or advocacy, reflects his commitment to building a more thoughtful and inclusive world.
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