George is a small, quick-witted man, while Lennie is a physically strong but mentally disabled man with a childlike innocence. The two have a close bond, with George serving as a protector and caretaker for Lennie.
The story follows their journey as they seek employment and dream of owning their own piece of land, which they call a little farm where they can live off the fat of the land. However, their dreams are constantly threatened by the harsh realities of their circumstances and the cruelty of the world around them.
The novella explores themes of friendship, loneliness, isolation, and the harshness of society, as well as the plight of marginalized individuals during the Great Depression. It is a poignant and timeless work that continues to resonate with readers due to its powerful portrayal of human relationships and the struggle for survival.