Five Membered Bioactive N and O-Heterocycles: Models and Medical Applications: Models and Medical Applications

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· IGI Global
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About this ebook

Five-membered bioactive heterocycles offer an in-depth exploration of the synthesis, properties, and wide-ranging medical applications of these molecular structures. From serving as the structural core of numerous pharmaceutical agents to directly engaging with biological targets, these molecules play a pivotal role in drug discovery and development. With applications spanning from antimicrobial and anticancer agents to treatments for neurological disorders, these compounds are integral to the design of targeted therapies. Their versatility and bioactivity make them valuable models for drug discovery, offering novel approaches to addressing a wide range of medical challenges. As research advances, the continued exploration of five-membered N- and O-heterocycles may help with the development of innovative treatments and the improvement of healthcare outcomes.

Five Membered Bioactive N and O-Heterocycles: Models and Medical Applications examines the synthetic methodologies employed in the construction of five-membered heterocycles, providing insights into the strategies and techniques utilized to access these diverse compounds. It delves into their synthetic pathways, including both traditional and modern synthetic approaches, along with the key factors influencing regio- and stereo-selectivity. This book covers topics such as bioactivity, chemistry, and pharmacology, this book is an excellent resource for chemists, pharmaceutical researchers and professionals, biochemists, molecular biologists, graduate and postgraduate students, academicians, healthcare professionals, and more.

About the author

|Shrikaant Kulkarni - Editor|Dr. Shrikaant Kulkarni Shrikaant Kulkarni , Ph.D., is currently working as an Adjunct Professor, Faculty of Business, Victorian Institute of Technology, Melbourne, Australia and Adjunct Professor at Chitkara University, Punjab, India. Dr. Kulkarni has been a senior academician and researcher for more than four decades. He has delivered invited lectures and conducted sessions at national and international conferences as well as faculty development programs. He has guided many major and minor projects in subject areas like engineering chemistry, green chemistry, nanotechnology, analytical chemistry, catalysis, chemical engineering materials, industrial organization, and management. He has published over 100+ research papers in national and international journals and conferences of repute. He has authored 50+ book chapters in books published by CRC, Springer Nature, Apple Academic Press, Elsevier, Wiley, and IET. He has edited 25+ books published by Apple Academic Press/CRC Press and Springer Nature. He authored four textbooks in engineering chemistry. Dr Kulkarni possesses MSc, MPhil, and PhD degrees in Chemistry in addition to master’s degrees in Economics, Business Management, and Political Science. He has expertise in the fields of green chemistry and engineering, analytical chemistry, green nanoscience and nanotechnology, wastewater treatment, Green and Analytical Chemistry, and advanced areas in Chemical Engineering and Material Science as well as Advanced AI. Two of his Patents have been published and two more are applied for grant.

Hemantkumar Akolkar , Ph.D., Working as Associate Professor, Department of Chemistry, Rayat Shikshan Sanstha's Abasaheb Marathe Arts and New Commerce, Science College, Rajapur, Dist- Ratnagiri, Maharashtra, India Dr. Hemantkumar N. Akolkar is an academician and researcher for last13 years at both undergraduate and postgraduate level. He has taught subjects like Heterocyclic Chemistry, Green Chemistry, Organic Spectroscopy, Organic Stereochemistry, Chemistry of Natural Products during his career. He possesses Masters in Organic chemistry and Ph.D. in Chemistry from Savitribai Phule Pune University, Pune. Hehas got 50+ research papers in national and international journals and conferences of repute. His areas of interest are Heterocyclic Chemistry, Synthetic Organic Chemistry and Green Chemistry. He is reviewer of several journals in Chemistry of international repute.

Bapurao B. Shingate , working as an Associate Professor in Organic Chemistry at Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada Univeresity, Aurangabad, Maharashtra, India Dr. Shingate has more than fifteen years of teaching and twenty-one years of research experience. He is teaching various topic to the postgraduate students like Organic reaction mechanism, Synthetic organic chemistry, Reagents in organic synthesis, Organometallic compounds, Protective groups, Retrosynthetic analysis, Classics in total synthesis, Multistep organic transformations, Asymmetric synthesis. Dr. Shingate is working on various areas of synthetic organic and medicinal chemistry and published more than 130 research papers in quality journals with good impact factors. He has published a review article in the prestigious journal Chemical Reviews (Impact factor 72.087). On his credit two Indian patents also. His total citations are 3849, h-index 35 and i-10 index is 96. He has immensely contributed in the field of design and synthesis of bioactive compounds and drug analogs, development of new synthetic methodologies, and total synthesis of natural and unnatural products. His cumulative impact factors are 506. Dr. Bapurao's contribution to teaching and research already been recognized in the university circle and national level. He has received several awards like GTEA-Best Chemistry Professor of the Year (2020), Bentham Ambassador (2018--23), ISCB-Best Teacher Award (2018), Dr. BAMU-Research Professor Award (2017), Dr. BAMU-Ideal Teacher Award (2014) and Dr. BAMU-Shikshak Pratibha Puraskar. Dr. Shingate has guided 07 Ph.D and more than 200 for M. Sc Dissertation. Dr. Shingate has delivered 175+ invited talks and BOS member in chemistry for several institutions. Dr. Shingate is editorial board member for several journals and reviewer for 60+ journals.

Vijay M Khedkar working as Associate Professor in the Department of Pharmacy at Vishwakarma University, Pune, Maharashtra, India A highly optimistic and proactive computational medicinal chemist with Ph.D. degree in Pharmaceutical Chemistry (Computational Medicinal Chemistry) and Post-doctoral research experience. Successful track record of executing lead identification and optimization projects by applying molecular modeling techniques. [Editor]

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