Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma

· · ·
· Academic Press
Ebook
644
Pages
Eligible
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About this ebook

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout.

These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma.

  • Contains contributions by international authors
  • Covers recent clinical trial advancements and findings and updates on ongoing trials
  • Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured
  • Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples

About the author

Dr. Fehlings is the Vice Chair Research for the Department of Surgery at the University of Toronto and Head of the Spinal Program at Toronto Western Hospital, University Health Network. Dr. Fehlings is a Professor of Neurosurgery at the University of Toronto, holds the Gerry and Tootsie Halbert Chair in Neural Repair and Regeneration, is a Scientist at the McEwen Centre for Regenerative Medicine and a McLaughlin Scholar in Molecular Medicine. In the fall of 2008, Dr. Fehlings was appointed the inaugural Director of the University of Toronto Neuroscience Program (which he held until June 2012) and is currently Co-Director of the University of Toronto Spine Program. Dr. Fehlings combines an active clinical practice in complex spinal surgery with a translationally oriented research program focused on discovering novel treatments to improve functional outcomes following spinal cord injury (SCI). He has published over 850 peer-reviewed articles (h-index 87) chiefly in the area of central nervous system injury and complex spinal surgery. His seminal 1991 paper, cited over 1400 times, outlined the severe and lasting consequences of SCI due to a cascade of secondary injury mechanisms following the initial trauma. His research on secondary injury mechanisms ultimately led to the commencement of the multicenter, international Surgical Timing in Acute Spinal Cord Injury Study (STASCIS), aimed at establishing the need for early surgical decompression to prevent the negative effects of the secondary injury cascade. The results from this study, led by Dr. Fehlings and published in 2012, demonstrated the critical importance of early surgical decompression (

Dr. Kwon is a surgeon-scientist with advanced training in spine surgery and also a PhD in neuroscience. He is a Professor in the UBC Department of Orthopaedics. As an attending orthopaedic spine surgeon at Vancouver General Hospital his practice is focused on the management of adult spine trauma, spinal cord injuries, and non-traumatic conditions such as spine infection, deformity, and degeneration. As a neuroscientist and Principal Investigator at ICORD, Dr. Kwon runs an active basic/translational research laboratory. Dr. Kwon is currently also serving as the Associate Director, Clinical Research, for ICORD, and is the Associate Scientific Director of the Rick Hansen Institute.

Dr. Vaccaro has served as the president of Rothman Orthopaedics since 2014 and is the Richard H. Rothman Professor and Chairman in the Department of Orthopaedic Surgery and Professor of Neurosurgery at Thomas Jefferson University in Philadelphia, Pennsylvania. He was the recipient of the Leon Wiltse award given for excellence in leadership and clinical research for spine care by the North American Spine Society (NASS) and is the past President of Cervical Spine Research Society (CSRS), the American Spinal Injury Association and the Association for Collaborative Spine Research. He is currently a member of the American Academy of Orthopaedic Surgeons (AAOS) Board of Directors. He has over 900 peer-reviewed and 200 non-peer reviewed publications. He has published over 372 book chapters and is the editor of over 63 textbooks and co-editor of OKU-Spine I and editor of OKU-8. Dr. Vaccaro also serves as Co-Director of the Regional Spinal Cord Injury Center of the Delaware Valley.

Cumhur Öner obtained in 1980 his Medical Degree in Ankara, Turkey and did his orthopaedic surgery training in Rotterdam between 1987 and 1993. Since 1993 he works as an orthopaedic spine surgeon at the University Medical Centre Utrecht. He obtained his PhD (cum laude) in 1999 from the University of Utrecht. The work for his PhD thesis focused on the diagnostic and prognostic parameters in spinal trauma patients. He is the head of the neuro-orthopaedic spine unit since 2002. Cumhur Öner has actively participated in the foundation of the international Spine Trauma Study Group and is currently member of the steering committee of the Knowledge Forum Trauma of the AOSpine International. He has been involved in clinical spine research as well as the bone and intervertebral disc RM program in the UMC Utrecht. He was the president of the Dutch Spine Society between 2007-2011.

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