This manual, developed by the World Health Organization (WHO) and the International Labour Organization (ILO), provides comprehensive guidelines on occupational safety and health during public health emergencies. It aims to protect health workers and responders from risks and hazards encountered during outbreaks and emergencies. The manual covers management system approaches, rights and duties of employers and workers, and health and safety surveillance, particularly referencing the Ebola virus disease response in West Africa. It also outlines strategies and tools, including the International Health Regulations and the Incident Command System, for managing such crises. The intended audience includes health workers, emergency responders, and policymakers involved in occupational health and public health preparedness.