Acute Promyelocytic Leukemia: A Clinical Guide
Oussama Abla · Francesco Lo Coco · Miguel A. Sanz
Apr 2018 · Springer
Ebook
274
Pages
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About this ebook
This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.
About the author
Oussama Abla, MD
The Hospital for Sick Children and University of Toronto
Division of Hematology/Oncology
Toronto, ON
Canada
Francesco Lo-Coco, MD
Professor of Hematology
University of Tor VergataRome
Italy
Miguel A. Sanz, MD
Centro de Investigación Biomédica en Red de Cáncer
Madrid
Spain
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