Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy

Peder Larson

Nov 2021 · Advances in Magnetic Resonance Technology and Applications Book 3 · Academic Press

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296

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About this ebook

MRI with hyperpolarized carbon-13 agents is a powerful emerging imaging modality that can measure real-time metabolism in cells, animals, and humans. It uses endogenous, non-toxic contrast agents that a hyperpolarized, resulting in up to 100,000-fold increases in sensitivity. This technique uses no ionizing radiation, and is being applied in a range of human trials. It's primary use is for metabolic imaging, but it can also measure perfusion, pH, and necrosis. Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy is designed to be a one stop shop for understanding hyperpolarized 13C MRI. This book explains the principles of this imaging modality, the requirements for performing studies, shows how to interpret the results, and gives an overview of current biomedical applications. It is suitable for engineers, scientists and clinicians in radiology and biomedical imaging who want to understand this technology. - Presents the physics and hardware of dissolution dynamic nuclear polarization - Explains the behaviour of hyperpolarized carbon-13 agents and how to image them - Detailed guidance on experimental design and data interpretation - Identifies promising and potential applications of hyperpolarized carbon-13 MR

About the author

Peder Larson, PhD, is an Associate Professor in Residence and a Principal Investigator in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Larson's research program is primarily centered around developing new MRI scanning and reconstruction technology for improved clinical outcomesDr. Peder Larson got his PhD under Dwight Nishimura from the Department of Electrical Engineering at Stanford University on "MRI of Semi-solid Tissues" in 2007. His research interests are in RF pulse design, pulse sequence development, novel imaging strategies, and optimized reconstruction methods for MRI, with an emphasis on applications in Hyperpolarized carbon-13 agents and semi-solid tissue imaging with ultrashort echo time (UTE) methods.

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