Necroptosis: A Programmed Cell Death Machinery in Human Health
Pratyusha Mandal
Mar 2026 · Academic Press
Ebook
300
Pages
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Eligible
info
infoThis book will become available on March 6, 2026. You will not be charged until it is released.
About this ebook
Necroptosis: A Programmed Cell Death Machinery in Human Health provides a comprehensive review of the evolving concepts of programmed cell death (PCD) machinery. The book traces the evolutionary origin of necroptosis, necroptotic proteins, and how the proteins contribute to necroptosis and other cell death pathways. It clarifies necroptosis as more than merely an alternate to extrinsic apoptosis but explores it as an inflammatory form of cell death interconnected with multiple death signaling that ultimately dictates physiological outcome. Coverage summarizes the role of the death pathway and proteins in mammalian health and disease as well as key diseases where they play recognized contributing roles. The involvement of necroptosis in pulmonary diseases including activation during SARS-CoV2 infection is covered along with other gastroenteric diseases, cancer, and aging. Beyond conveying clinical knowledge, these topics will be of strong research interest to the biomedical bench scientist. - Explains programmed cell death machinery as ubiquitous in all eukaryotes and as fundamentally related to health and disease in mammals - Elucidates necroptosis as a factor of tissue injury in high relevant human diseases including COVID-19 - Explains the suppression of necroptosis and other cell death pathways as a key modus operandi by pathogens
About the author
Pratyusha Mandal, PhD is an adjunct professor in the Department of Microbiology and Immunology at Emory University. Her main research areas focus on mucosal inflammatory diseases including acute, as well as chronic pulmonary and intestinal pathologies. She is the recipient of the 2021-2023 Cystic Fibrosis Foundation Pilot and Feasibility Award, won the 2021-1st Position in Emory Winship Discovery and Developmental Therapeutics competition. She is a member of the American Society for Microbiology, American Society for Virology, and was a participant in the Women in Science Program at Purdue University from 2006-2012 as well as a board member of the National Postdoctoral Association from 2015-2018.
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