Neuropathology of Aging and Alzheimer's Disease
Rudy J. Castellani
May 2025 · Elsevier
Ebook
320
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About this ebook
Neuropathology of Aging and Alzheimer's Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer's Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention. Detailed discussion and analysis of early Alzheimer's disease investigators and their findingsDetailed discussion and analysis of the often-overlooked literature from the 1920's to the 1960'sDetailed discussion and analysis of aging-related phenomena currently under studyDetailed discussion and analysis of punch-drunk syndrome and the transition to modern understanding of chronic traumatic encephalopathyDetailed discussion and analysis of the pathology of autosomal dominant Alzheimer's disease and Alzheimer's disease associated with Down syndromePractical issues with diagnosing and reporting Alzheimer's disease and aging-related changes
About the author
Dr. Rudy Castellani is a professor in the Division of Neuropathology at the Northwestern University Feinberg School of Medicine, the Program Director for the Neuropathology Fellowship Training Program, and the Neuropathology Core Director for the Northwestern University Alzheimer's Disease Research Center at the Mesulam Center for Cognitive Neurology. He is the recipient of the 2010 Alzheimer medal from the Journal of Alzheimer's disease. He was formerly professor and vice chair of research, at West Virginia University and the Rockefeller Neuroscience institute, and a former tenured professor and director of neuropathology at University of Maryland, Baltimore. Dr. Castellani has authored or co-authored over 330 research articles, reviews, and chapters, with a focus on neurodegenerative diseases and neurotrauma, and has been quoted in the New York Times on issues related to Alzheimer's disease treatment.
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