Behavioral Genetics of the Mouse: Volume 2, Genetic Mouse Models of Neurobehavioral Disorders

Susanna Pietropaolo · Frans Sluyter · Wim E. Crusio

Sep 2014 · Cambridge University Press

Ebook

471

Pages

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About this ebook

The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

About the author

Susanna Pietropaolo is a Researcher at the Centre National de la Recherche Scientifique (CNRS). She is an expert in the behavioral analysis of the laboratory mouse, with a special interest in social behaviors. Her recent research focuses on mouse models of social dysfunction, including autism and Fragile X syndrome.

Frans Sluyter is an expert in (wild) house mouse behavior and neurogenetics. His interests range from aggression, addiction, depression and (stress) coping strategies to gene expression profiles and consciousness. He has worked in The Netherlands, France, Japan and England.

Wim E. Crusio is a Research Director at the Centre National de la Recherche Scientifique (CNRS). With over 35 years' experience in mouse behavioral neurogenetics and the analysis of mouse behavior, his recent interests cover mouse models of depression, autism, and Fragile X syndrome.

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