This document outlines the World Health Organization's strategy for preventing and responding to sexual misconduct over a three-year period from 2023 to 2025. It details the WHO's approach to strengthening transparency, embedding victim-centered processes, and integrating safeguarding measures into relevant policies and practices. The strategy emphasizes cultural change within the organization, prioritizes high-risk situations such as emergencies, and aims to enhance the systems for identifying and managing risks. Additionally, it seeks to build capacity and expertise while implementing a comprehensive incident management system. The document is intended for stakeholders involved in public health, humanitarian efforts, and organizational governance.