This policy brief, published by the World Health Organization in 2023, focuses on providing care for individuals with advanced HIV disease who are seriously ill. It addresses the importance of early diagnosis and treatment to prevent AIDS-related deaths, particularly in regions with high HIV prevalence. The brief outlines guidelines for managing advanced HIV disease, including initial management, screening, diagnostic testing, and treatment of opportunistic infections. It emphasizes the need for ART management, symptom management, and palliative care. The document is intended for healthcare professionals, country HIV program officers, hospital management, and international organizations involved in HIV care, especially in low- and middle-income countries.