This report from the World Health Organization (WHO) details the global efforts and outcomes related to water, sanitation, and hygiene (WASH) in 2020. It highlights WHO's response to the COVID-19 pandemic, focusing on the provision of critical data and technical guidance for managing water, sanitation, hygiene, and waste in the context of SARS-CoV-2. The report covers the organization's ongoing WASH programs, the Joint Monitoring Programme for Water Supply, Sanitation, and Hygiene (JMP), and the UN-Water Global Analysis and Assessment of Sanitation and Drinking-Water (GLAAS). Key achievements include the dissemination of WASH guidelines and the integration of WASH with other health initiatives to combat antimicrobial resistance. The report underscores WHO's strategic partnerships and advocacy efforts to improve global access to safe water and sanitation, especially during the pandemic.