The 'Global Polio Eradication Initiative Investment Case 2022-2026' is a strategic document published by the World Health Organization that outlines the critical steps and financial commitments required to achieve a polio-free world. With a focus on the last remaining challenges in eradicating polio, the initiative aims to secure a $4.8 billion investment over five years to support immunization operations, surveillance, and health system strengthening, particularly in high-risk and endemic countries like Pakistan and Afghanistan. The document addresses the need for global commitment, community engagement, and integration of eradication efforts with broader health goals. It emphasizes the urgency of action due to disruptions caused by the COVID-19 pandemic and ongoing geopolitical challenges. The initiative is presented as both a health imperative and an investment in a healthier future, ensuring benefits beyond polio eradication.