Direct Nose-to-Brain Drug Delivery: Mechanism, Technological Advances, Applications, and Regulatory Updates

Chandrakantsing Pardeshi · Eliana B. Souto

Jun 2021 · Academic Press

Ebook

554

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About this ebook

Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments. - Explains the targeting approaches for enhanced brain targeting following intranasal drug administration - Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose-to-brain - Discusses pharmaceutical and biomedical applications after nose-to-brain delivery of therapeutic pharmaceuticals and biologicals

About the author

Dr. Chandrakantsing Pardeshi holds PhD degree in Pharmaceutical Sciences from Kavayitri Bahinabai Chaudhari North Maharashtra University (KBC NMU, India). Presently, he is an Associate Professor of Pharmaceutics at R. C. Patel Institute of Pharmaceutical Education and Research (Shirpur, India) where he is inventing the novel devices for direct nose-to-brain drug delivery. Dr. Pardeshi has authored more than 50 peer-reviewed publications, 21 book chapters and several research abstracts. He has, to his credit, 2 Indian patents and 1 research project funded by University Grants Commission (New Delhi, India). He is an active referee and editorial board member of few reputed multidisciplinary international journals. Dr. Pardeshi also contributed as a Grant evaluator in Government Funding bodies. He has been awarded with Gold Medal from KBC NMU (India), and Excellence Award from Indian Drug Manufacturer’s Association (IDMA, India).

Eliana B. Souto is Habil. Professor from the Department of Pharmaceutical Technology of the Faculty of Pharmacy of University of Porto. Prof. Souto graduated in Pharmaceutical Sciences from University of Coimbra (2000), is holder of a master’s in science degree in Pharmaceutical Technology from University of Porto (2002), and PhD in Pharmaceutical Nanotechnology and Biopharmaceutics from the Institut fuer Pharmazie der Freie Universitaet Berlin, Germany (2005). Her research lines include the design, development, and characterization of new drug delivery systems to overcome biological barriers. Prof. Souto serves as Associate Editor, member of the Editorial Board, and Reviewer of several international scientific journals and has published more than 500 works (original and review papers, books and book chapters) in the field of nanosciences and nanomedicine. Prof. Souto also acts as independent expert for several national, European and international funding agencies, and as consultant for pharmaceutical industry.

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